G-CSF R/CD114, His, Human

G-CSF R/CD114, His, Human

The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal.
Z05338
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Product Introduction
Species Human
Protein Construction
G-CSF R/CD114 (Glu25-His627)
Accession # Q99062-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized G-CSF R/CD114, His, Human at 1μg/ml (100μl/well) on the plate can bind Human G­CSF, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 68.29 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal.
Synonyms G-CSF-R; G-CSF R; CD114; G CSF R; CSF3R; Csfgr; GCSFR

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.