GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human
GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human

Immobilized GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human, His Tag at 5 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-GARP&TGF beta 1 Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA.

GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human

The purity of GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human

GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human

GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-β and thus promoting secretion and activation of TGF-β. Integrin αvβ8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-β from the TGF-β&GARP complex.
Z05330
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Product Introduction
Species Human
Protein Construction
GARP (Y137H) & Latent TGF Beta 1 Complex [His20-Leu628 (GARP (Y137H)) and Leu30-Ser390 (Latent TGF Beta 1)]
Accession # Q14392 (GARP (Y137H)) & P01137 (Latent TGF beta 1)		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 70.3 kDa (GARP(Y137H)) and 41.4 kDa (Latent TGF Beta 1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 71-75 kDa (GARP(Y137H)), 13 kDa and 42-45 kDa (Latent TGF Beta 1) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human
    • GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human

    Immobilized GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human, His Tag at 5 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-GARP&TGF beta 1 Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA.

  • GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human
    • GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human

    The purity of GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human
    • GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human

    GARP (Y137H) &Latent TGF Beta 1 Complex, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-β and thus promoting secretion and activation of TGF-β. Integrin αvβ8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-β from the TGF-β&GARP complex.
Synonyms LRRC32; GARP; LAP; TGF-beta-1; LRRC32&TGF-beta 1; LRRC32&TGFB1; TGF-β-1; LRRC32&TGF-β 1; GARP&Latent TGF Beta; GARP&Latent TGF Beta 1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.