FGFR3 alpha (IIIb), His & Avi, Human
FGFR3 Alpha (IIIb), His & Avi, Human

Immobilized FGFR3 alpha (IIIb), His & Avi, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.

FGFR3 Alpha (IIIb), His & Avi, Human

The purity of FGFR3 alpha (IIIb), His & Avi, Human is greater than 95% as determined by SEC-HPLC.

FGFR3 Alpha (IIIb), His & Avi, Human

FGFR3 alpha (IIIb), His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

FGFR3 alpha (IIIb), His & Avi, Human

Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Z05298
¥52,232.00

Ask us a question
Product Introduction
Species Human
Protein Construction
FGFR3 alpha (IIIb) (Glu23-Gly377)
Accession # P22607-2		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 41.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • FGFR3 Alpha (IIIb), His & Avi, Human
    • FGFR3 Alpha (IIIb), His & Avi, Human

    Immobilized FGFR3 alpha (IIIb), His & Avi, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-FGFR3 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA.

  • FGFR3 Alpha (IIIb), His & Avi, Human
    • FGFR3 Alpha (IIIb), His & Avi, Human

    The purity of FGFR3 alpha (IIIb), His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • FGFR3 Alpha (IIIb), His & Avi, Human
    • FGFR3 Alpha (IIIb), His & Avi, Human

    FGFR3 alpha (IIIb), His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.


Background
Target Background Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Synonyms ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.