FDPS, His, Human
FDPS, His, Human

The purity of FDPS, His, Human is greater than 95% as determined by SEC-HPLC.

FDPS, His, Human

FDPS, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FDPS, His, Human

Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of diseases, including bone-related disorders characterized by excessive bone resorption, for example, osteoporosis, cancer metathesis to bone and infectious diseases caused by certain parasites.
Z05286
¥69,021.00

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Product Introduction
Species Human
Protein Construction
His FDPS (Met1-Lys353)
Accession # NP_001129294.1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System E.coli
Theoretical Molecular Weight 41.93 kDa
Apparent Molecular Weight The protein has a predicted MW of 41.93 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • FDPS, His, Human
    • FDPS, His, Human

    The purity of FDPS, His, Human is greater than 95% as determined by SEC-HPLC.

  • FDPS, His, Human
    • FDPS, His, Human

    FDPS, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of diseases, including bone-related disorders characterized by excessive bone resorption, for example, osteoporosis, cancer metathesis to bone and infectious diseases caused by certain parasites.
Synonyms FPP; FPS; KIAA1293; FPPS

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.