FcRH6 /FCRL6 hFc Chimera, Human
FcRH6 /FCRL6 HFc Chimera, Human

FcRH6 /FCRL6 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

FcRH6 /FCRL6 hFc Chimera, Human

A surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1-6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular immunoglobulin domains of five different subtypes. All but one of these new receptors, FcRH6, are expressed on B cells at different stages in differentiation.
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Product Introduction
Species Human
Protein Construction
FcRH6 /FCRL6 (Leu20-Trp307)
Accession # Q6DN72-1		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 58.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • FcRH6 /FCRL6 HFc Chimera, Human
    • FcRH6 /FCRL6 HFc Chimera, Human

    FcRH6 /FCRL6 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background A surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1-6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular immunoglobulin domains of five different subtypes. All but one of these new receptors, FcRH6, are expressed on B cells at different stages in differentiation.
Synonyms FcR-like protein 6; FcRL6; FcRH6; IFGP6; Fc receptor-like 6; FLJ16056

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.