Fc gamma RIIIB/CD16b (NA1), His, Human
Fc Gamma RIIIB/CD16b (NA1), His, Human

The purity of Fc gamma RIIIB/CD16b (NA1), His, Human is greater than 95% as determined by SEC-HPLC.

Fc Gamma RIIIB/CD16b (NA1), His, Human

Fc gamma RIIIB/CD16b (NA1), His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Fc Gamma RIIIB/CD16b (NA1), His, Human

Fc gamma RIIIB/CD16b (NA1), His, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Rituximab with an affinity constant of 8.55 μM as determined in SPR assay (Biacore T200).

Fc gamma RIIIB/CD16b (NA1), His, Human

Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Z05279
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Product Introduction
Species Human
Protein Construction
Fc gamma RIIIB/CD16b (NA1) [Gly17-Ser200 (NA1)]
Accession # AAA35881.1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded Fc gamma RIIIB/CD16b (NA1), His, Human on Anti-His-Biosensor can bind Rituximab in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22.52 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Fc Gamma RIIIB/CD16b (NA1), His, Human
    • Fc Gamma RIIIB/CD16b (NA1), His, Human

    The purity of Fc gamma RIIIB/CD16b (NA1), His, Human is greater than 95% as determined by SEC-HPLC.

  • Fc Gamma RIIIB/CD16b (NA1), His, Human
    • Fc Gamma RIIIB/CD16b (NA1), His, Human

    Fc gamma RIIIB/CD16b (NA1), His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Fc Gamma RIIIB/CD16b (NA1), His, Human
    • Fc Gamma RIIIB/CD16b (NA1), His, Human

    Fc gamma RIIIB/CD16b (NA1), His, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Rituximab with an affinity constant of 8.55 μM as determined in SPR assay (Biacore T200).


Background
Target Background Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Synonyms CD16; Fc gamma RIIIB; FCG3; FCGR3B; FcgRIIIB; FCRIIIB; IGFR3; CD16b (NA2); CD16B; FCG3B; FCG3; FCGR3; FCR-10

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.