Fc epsilon RI alpha/FCER1a hFc Chimera, Human
Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human

Immobilized Fc epsilon RI alpha/FCER1a hFc Chimera, Human, hFc Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-Fc epsilon RI alpha Antibody, hFc-Avi Tag with the EC50 of 20.3ng/ml determined by ELISA.

Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human

The purity of Fc epsilon RI alpha/FCER1a hFc Chimera, Human is greater than 90% as determined by SEC-HPLC.

Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human

Fc epsilon RI alpha/FCER1a hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Fc epsilon RI alpha/FCER1a hFc Chimera, Human

Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic diseases, and appears to participate in the systemic regulation of IgE levels.
Z05274
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Product Introduction
Species Human
Protein Construction
Fc epsilon RI alpha/FCER1a (Val26-Gln205)_x000D_
Accession # P12319-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 47.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-78 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human
    • Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human

    Immobilized Fc epsilon RI alpha/FCER1a hFc Chimera, Human, hFc Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-Fc epsilon RI alpha Antibody, hFc-Avi Tag with the EC50 of 20.3ng/ml determined by ELISA.

  • Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human
    • Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human

    The purity of Fc epsilon RI alpha/FCER1a hFc Chimera, Human is greater than 90% as determined by SEC-HPLC.

  • Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human
    • Fc Epsilon RI Alpha/FCER1a HFc Chimera, Human

    Fc epsilon RI alpha/FCER1a hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic diseases, and appears to participate in the systemic regulation of IgE levels.
Synonyms Fc-epsilon RI-alpha; FcERI; FCER1A; FCE1A

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.