Factor H/CFH, His, Human
Factor H/CFH, His, Human

Immobilized Factor H/CFH, His, Human, His Tag at 0.5 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-Factor H Antibody, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA.

Factor H/CFH, His, Human

The purity of Factor H/CFH, His, Human is greater than 90% as determined by SEC-HPLC.

Factor H/CFH, His, Human

Factor H/CFH, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Factor H/CFH, His, Human

Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.
Z05267
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Product Introduction
Species Human
Protein Construction
Factor H/CFH (Ser860-Arg1231)_x000D_
Accession # P08603-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 42.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Factor H/CFH, His, Human
    • Factor H/CFH, His, Human

    Immobilized Factor H/CFH, His, Human, His Tag at 0.5 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-Factor H Antibody, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA.

  • Factor H/CFH, His, Human
    • Factor H/CFH, His, Human

    The purity of Factor H/CFH, His, Human is greater than 90% as determined by SEC-HPLC.

  • Factor H/CFH, His, Human
    • Factor H/CFH, His, Human

    Factor H/CFH, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.
Synonyms Complement factor H; H factor 1; CFH; HF; HF1; HF2; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH; FHL1; HUS

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.