EphB3, His, Human
EphB3, His, Human

The purity of EphB3, His, Human is greater than 95% as determined by SEC-HPLC.

EphB3, His, Human

EphB3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

EphB3, His, Human

Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is contributed to downregulation of EphB3 in CRC. EphB3 expression in tumor cells may be a useful prognostic indicator for patients with CRC.
Z05255
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Product Introduction
Species Human
Protein Construction
EphB3 (Gly34-Leu559)
Accession # P54753		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 58.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM Tris, 150mM NaCl (pH 7.5).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • EphB3, His, Human
    • EphB3, His, Human

    The purity of EphB3, His, Human is greater than 95% as determined by SEC-HPLC.

  • EphB3, His, Human
    • EphB3, His, Human

    EphB3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is contributed to downregulation of EphB3 in CRC. EphB3 expression in tumor cells may be a useful prognostic indicator for patients with CRC.
Synonyms EK2; ETK2; HEK2; TYRO6; EPHB3; AW456895; Cek10; MDK5; Sek4; EC 2.7.10; EC 2.7.10.1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.