EPHA3, His, Human
EPHA3, His, Human

The purity of EPHA3, His, Human is greater than 95% as determined by SEC-HPLC.

EPHA3, His, Human

EPHA3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

EPHA3, His, Human

Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. The interaction of AR and SP1 contributes to regulate EPHA3 expression, and the SP1 binding sites (‑295~‑261) in the EPHA3 core promoter region is crucial to the regulation of EPHA3 expression in response to androgen hormone stimuli.
Z05250
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Product Introduction
Species Human
Protein Construction
EPHA3 (Glu21-Gln541)
Accession # P29320-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 59.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • EPHA3, His, Human
    • EPHA3, His, Human

    The purity of EPHA3, His, Human is greater than 95% as determined by SEC-HPLC.

  • EPHA3, His, Human
    • EPHA3, His, Human

    EPHA3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. The interaction of AR and SP1 contributes to regulate EPHA3 expression, and the SP1 binding sites (‑295~‑261) in the EPHA3 core promoter region is crucial to the regulation of EPHA3 expression in response to androgen hormone stimuli.
Synonyms EK4; HEK; ETK; ETK1; EPHA3; TYRO4; HEK4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.