DR6/TNFRSF21, His, Human
DR6/TNFRSF21, His, Human

Immobilized DR6/TNFRSF21, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DR6 Antibody, hFc Tag with the EC50 of 4.6 ng/ml determined by ELISA.

DR6/TNFRSF21, His, Human

DR6/TNFRSF21, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

DR6/TNFRSF21, His, Human

beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro.DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation.
Z05226
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Product Introduction
Species Human
Protein Construction
DR6/TNFRSF21 (Gln42-His349)
Accession # O75509		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized DR6/TNFRSF21, His, Human at 0.5μg/ml (100μl/well) on the plate can bind Anti­DR6 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 34.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • DR6/TNFRSF21, His, Human
    • DR6/TNFRSF21, His, Human

    Immobilized DR6/TNFRSF21, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DR6 Antibody, hFc Tag with the EC50 of 4.6 ng/ml determined by ELISA.

  • DR6/TNFRSF21, His, Human
    • DR6/TNFRSF21, His, Human

    DR6/TNFRSF21, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro.DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation.
Synonyms Death receptor 6; CD358; TNFRSF21; DR6; BM-018; MGC31965

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.