DcR1/TRAILR3, His, Human
DcR1/TRAILR3, His, Human

The purity of DcR1/TRAILR3, His, Human is greater than 95% as determined by SEC-HPLC.

DcR1/TRAILR3, His, Human

DcR1/TRAILR3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

DcR1/TRAILR3, His, Human

DcR1/TRAILR3, His, Human on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.57 nM as determined in SPR assay (Biacore T200).

DcR1/TRAILR3, His, Human

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family, which mediates apoptosis by the extrinsic pathway. Up-regulation of decoy receptors, DcR1 and DcR2, may result in diminished binding of TRAIL to their functional receptors. DcR1 expression occurs in a subset of EC and may contribute to resistance to TRAIL-induced apoptosis.
Z05210
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Product Introduction
Species Human
Protein Construction
DcR1/TRAILR3 (Tyr24-Ala236)
Accession # Q05D71		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity DcR1/TRAILR3, His, Human immobilized on CM5 Chip can bind Human TRAIL, No Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 23.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • DcR1/TRAILR3, His, Human
    • DcR1/TRAILR3, His, Human

    The purity of DcR1/TRAILR3, His, Human is greater than 95% as determined by SEC-HPLC.

  • DcR1/TRAILR3, His, Human
    • DcR1/TRAILR3, His, Human

    DcR1/TRAILR3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • DcR1/TRAILR3, His, Human
    • DcR1/TRAILR3, His, Human

    DcR1/TRAILR3, His, Human on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.57 nM as determined in SPR assay (Biacore T200).


Background
Target Background The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family, which mediates apoptosis by the extrinsic pathway. Up-regulation of decoy receptors, DcR1 and DcR2, may result in diminished binding of TRAIL to their functional receptors. DcR1 expression occurs in a subset of EC and may contribute to resistance to TRAIL-induced apoptosis.
Synonyms CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID; TNFRSF10C

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.