CLEC7A hFc Chimera, Human
CLEC7A HFc Chimera, Human

The purity of CLEC7A hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

CLEC7A HFc Chimera, Human

CLEC7A hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

CLEC7A hFc Chimera, Human

Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders.
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Product Introduction
Species Human
Protein Construction
hFc CLEC7A (Thr66-Met201)
Accession # Q9BXN2-2
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 41.79 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • CLEC7A HFc Chimera, Human
    • CLEC7A HFc Chimera, Human

    The purity of CLEC7A hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • CLEC7A HFc Chimera, Human
    • CLEC7A HFc Chimera, Human

    CLEC7A hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Dendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). Dectin-1 signaling axis has been suggested to be targeted as an effective therapeutic strategy for cancers. Dectin-1 has also been elucidated ascetically in the heart, respiratory, intestinal, neurological and developmental disorders.
Synonyms Beta-glucan receptor; DC-associated C-type lectin 1; Dectin-1; Dectin1; CD369; BGR; CLECSF12; DECTIN1; CANDF4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.