CDH17/Cadherin 17 hFc Chimera, Human
CDH17/Cadherin 17 HFc Chimera, Human

Loaded Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag on Streptavidin-Biosensor can bind CDH17/Cadherin 17 hFc Chimera, Human, hFc Tag with an affinity constant of 0.14 nM as determined in BLI assay (Gator® Prime).

CDH17/Cadherin 17 HFc Chimera, Human

Immobilized CDH17/Cadherin 17 hFc Chimera, Human, hFc Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag with the EC50 of 15.3ng/ml determined by ELISA.

CDH17/Cadherin 17 HFc Chimera, Human

The purity of CDH17/Cadherin 17 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

CDH17/Cadherin 17 HFc Chimera, Human

CDH17/Cadherin 17 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%

CDH17/Cadherin 17 hFc Chimera, Human

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Z05154
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Product Introduction
Species Human
Protein Construction
CDH17/Cadherin 17 (Gln23-Met787)
Accession # Q12864		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 111.73 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 113-135 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • CDH17/Cadherin 17 HFc Chimera, Human
    • CDH17/Cadherin 17 HFc Chimera, Human

    Loaded Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag on Streptavidin-Biosensor can bind CDH17/Cadherin 17 hFc Chimera, Human, hFc Tag with an affinity constant of 0.14 nM as determined in BLI assay (Gator® Prime).

  • CDH17/Cadherin 17 HFc Chimera, Human
    • CDH17/Cadherin 17 HFc Chimera, Human

    Immobilized CDH17/Cadherin 17 hFc Chimera, Human, hFc Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag with the EC50 of 15.3ng/ml determined by ELISA.

  • CDH17/Cadherin 17 HFc Chimera, Human
    • CDH17/Cadherin 17 HFc Chimera, Human

    The purity of CDH17/Cadherin 17 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • CDH17/Cadherin 17 HFc Chimera, Human
    • CDH17/Cadherin 17 HFc Chimera, Human

    CDH17/Cadherin 17 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%


Background
Target Background Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Synonyms Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.