CA9/Carbonic Anhydrase IX hFc Chimera, Human
CA9/Carbonic Anhydrase IX HFc Chimera, Human

Immobilized CA9/Carbonic Anhydrase IX hFc Chimera, Human, hFc Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Biotinylated Anti-CA9 Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA.

CA9/Carbonic Anhydrase IX HFc Chimera, Human

The purity of CA9/Carbonic Anhydrase IX hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

CA9/Carbonic Anhydrase IX HFc Chimera, Human

CA9/Carbonic Anhydrase IX hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

CA9/Carbonic Anhydrase IX hFc Chimera, Human

CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways.
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Product Introduction
Species Human
Protein Construction
CA9/Carbonic Anhydrase IX (Gln38-Asp414)
Accession # Q16790		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. Measured by its esterase activity. Test result meets the standard.
Expression System HEK293
Theoretical Molecular Weight 66.91 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • CA9/Carbonic Anhydrase IX HFc Chimera, Human
    • CA9/Carbonic Anhydrase IX HFc Chimera, Human

    Immobilized CA9/Carbonic Anhydrase IX hFc Chimera, Human, hFc Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Biotinylated Anti-CA9 Antibody, hFc Tag with the EC50 of 7.4ng/ml determined by ELISA.

  • CA9/Carbonic Anhydrase IX HFc Chimera, Human
    • CA9/Carbonic Anhydrase IX HFc Chimera, Human

    The purity of CA9/Carbonic Anhydrase IX hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • CA9/Carbonic Anhydrase IX HFc Chimera, Human
    • CA9/Carbonic Anhydrase IX HFc Chimera, Human

    CA9/Carbonic Anhydrase IX hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways.
Synonyms CA9; CAIX; CA-IX; EC 4.2.1.1; G250; MN; P54/58N; PMW1; RCC

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.