BAFFR/TNFRSF13C hFc Chimera, Human
BAFFR/TNFRSF13C HFc Chimera, Human

BAFFR/TNFRSF13C hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

BAFFR/TNFRSF13C HFc Chimera, Human

Immobilized BAFFR/TNFRSF13C hFc Chimera, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human BAFFR, hFc Tag with the EC50 of 62.5ng/ml determined by ELISA.

BAFFR/TNFRSF13C hFc Chimera, Human

BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
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Product Introduction
Species Human
Protein Construction
BAFFR/TNFRSF13C (Ser7-Ala71)
Accession # Q96RJ3-1		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 33.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-48 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • BAFFR/TNFRSF13C HFc Chimera, Human
    • BAFFR/TNFRSF13C HFc Chimera, Human

    BAFFR/TNFRSF13C hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • BAFFR/TNFRSF13C HFc Chimera, Human
    • BAFFR/TNFRSF13C HFc Chimera, Human

    Immobilized BAFFR/TNFRSF13C hFc Chimera, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human BAFFR, hFc Tag with the EC50 of 62.5ng/ml determined by ELISA.


Background
Target Background BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
Synonyms CD268; BAFFR; BR3; TNFRSF13C; BROMIX; CVID4; prolixin

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.