B2M/beta 2-Microglobulin hFc Chimera, Human
B2M/beta 2-Microglobulin HFc Chimera, Human

The purity of B2M/beta 2-Microglobulin hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

B2M/beta 2-Microglobulin HFc Chimera, Human

B2M/beta 2-Microglobulin hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

B2M/beta 2-Microglobulin hFc Chimera, Human

To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly higher than that found in normal synovial fluid. B2M is highly expressed in OA cartilage and synovial fluid compared to normal, and suggest that B2M may have effects on chondrocyte function that could contribute to OA pathogenesis.
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Product Introduction
Species Human
Protein Construction
B2M/beta 2-Microglobulin (Ile21-Met119)
Accession # P61769-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 38.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • B2M/beta 2-Microglobulin HFc Chimera, Human
    • B2M/beta 2-Microglobulin HFc Chimera, Human

    The purity of B2M/beta 2-Microglobulin hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • B2M/beta 2-Microglobulin HFc Chimera, Human
    • B2M/beta 2-Microglobulin HFc Chimera, Human

    B2M/beta 2-Microglobulin hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly higher than that found in normal synovial fluid. B2M is highly expressed in OA cartilage and synovial fluid compared to normal, and suggest that B2M may have effects on chondrocyte function that could contribute to OA pathogenesis.
Synonyms Beta-2-microglobulin;B2M;β-2-microglobulin

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.