APOE3/Apolipoprotein E hFc Chimera, Human
APOE3/Apolipoprotein E HFc Chimera, Human

APOE3/Apolipoprotein E hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

APOE3/Apolipoprotein E HFc Chimera, Human

APOE3/Apolipoprotein E hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human TREM2, His Tag with an affinity constant of 20.24 μM as determined in SPR assay (Biacore T200).

APOE3/Apolipoprotein E hFc Chimera, Human

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
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Product Introduction
Species Human
Protein Construction
hFc APOE3/Apolipoprotein E (Lys19-His317)
Accession # P02649
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human TREM2, His Tag captured on CM5 Chip via anti­his antibody can bind APOE3/Apolipoprotein E hFc Chimera, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 59.76 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • APOE3/Apolipoprotein E HFc Chimera, Human
    • APOE3/Apolipoprotein E HFc Chimera, Human

    APOE3/Apolipoprotein E hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • APOE3/Apolipoprotein E HFc Chimera, Human
    • APOE3/Apolipoprotein E HFc Chimera, Human

    APOE3/Apolipoprotein E hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human TREM2, His Tag with an affinity constant of 20.24 μM as determined in SPR assay (Biacore T200).


Background
Target Background Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
Synonyms Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.