APOE2/Apolipoprotein E, His, Human
APOE2/Apolipoprotein E, His, Human

The purity of APOE2/Apolipoprotein E, His, Human is greater than 95% as determined by SEC-HPLC.

APOE2/Apolipoprotein E, His, Human

APOE2/Apolipoprotein E, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

APOE2/Apolipoprotein E, His, Human

Human TREM2, hFc Tag captured on CM5 Chip via Protein A can bind APOE2/Apolipoprotein E, His, Human, His Tag with an affinity constant of 27.11 nM as determined in SPR assay (Biacore T200).

APOE2/Apolipoprotein E, His, Human

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
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Product Introduction
Species Human
Protein Construction
APOE2/Apolipoprotein E [Lys19-His317 (R176C)]
Accession # P02649-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human TREM2, hFc Tag captured on CM5 Chip via Protein A can bind APOE2/Apolipoprotein E, His, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 35.28 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-42 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • APOE2/Apolipoprotein E, His, Human
    • APOE2/Apolipoprotein E, His, Human

    The purity of APOE2/Apolipoprotein E, His, Human is greater than 95% as determined by SEC-HPLC.

  • APOE2/Apolipoprotein E, His, Human
    • APOE2/Apolipoprotein E, His, Human

    APOE2/Apolipoprotein E, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • APOE2/Apolipoprotein E, His, Human
    • APOE2/Apolipoprotein E, His, Human

    Human TREM2, hFc Tag captured on CM5 Chip via Protein A can bind APOE2/Apolipoprotein E, His, Human, His Tag with an affinity constant of 27.11 nM as determined in SPR assay (Biacore T200).


Background
Target Background Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
Synonyms APOE2; APOE; Apo-E

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.