AMCase/CHIA, His, Human
AMCase/CHIA, His, Human

The purity of AMCase/CHIA, His, Human is greater than 95% as determined by SEC-HPLC.

AMCase/CHIA, His, Human

AMCase/CHIA, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

AMCase/CHIA, His, Human

Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. Despite that AMCase expression in the inflammation is under investigation, little is known regarding its regulation during macrophages' full maturation and polarization.
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Product Introduction
Species Human
Protein Construction
AMCase/CHIA (Tyr22-Ala476)
Accession # Q9BZP6-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 51.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • AMCase/CHIA, His, Human
    • AMCase/CHIA, His, Human

    The purity of AMCase/CHIA, His, Human is greater than 95% as determined by SEC-HPLC.

  • AMCase/CHIA, His, Human
    • AMCase/CHIA, His, Human

    AMCase/CHIA, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. Despite that AMCase expression in the inflammation is under investigation, little is known regarding its regulation during macrophages' full maturation and polarization.
Synonyms Acidic mammalian chitinase; AMCase; CHIA; CHIT2; EC 3.2.1.14; Chia1; YNL

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.