Aggrecan, His, Human
Aggrecan, His, Human

The purity of Aggrecan, His, Human is greater than 95% as determined by SEC-HPLC.

Aggrecan, His, Human

Aggrecan, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Aggrecan, His, Human

Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vessels during cardiovascular development. Whereas aggrecan is essential for skeletal development, its function in the developing cardiovascular system remains to be fully elucidated.
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Product Introduction
Species Human
Protein Construction
Aggrecan (Ala17-Leu721)
Accession # Q6PID9		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 78.86 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 90-130 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Aggrecan, His, Human
    • Aggrecan, His, Human

    The purity of Aggrecan, His, Human is greater than 95% as determined by SEC-HPLC.

  • Aggrecan, His, Human
    • Aggrecan, His, Human

    Aggrecan, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vessels during cardiovascular development. Whereas aggrecan is essential for skeletal development, its function in the developing cardiovascular system remains to be fully elucidated.
Synonyms ACAN; AGC1; CSPG1; MSK16

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.