AFP, His, Human
AFP, His, Human

The purity of AFP, His, Human is greater than 95% as determined by SEC-HPLC.

AFP, His, Human

AFP, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

AFP, His, Human

Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases.
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Product Introduction
Species Human
Protein Construction
AFP (Arg19-Val609)
Accession # P02771		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 67.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-72 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • AFP, His, Human
    • AFP, His, Human

    The purity of AFP, His, Human is greater than 95% as determined by SEC-HPLC.

  • AFP, His, Human
    • AFP, His, Human

    AFP, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases.
Synonyms Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-feto; AFP; HPAFP; AFPD; FETA

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.