ACVR1B/Activin RIB, His, Human
ACVR1B/Activin RIB, His, Human

The purity of ACVR1B/Activin RIB, His, Human is greater than 95% as determined by SEC-HPLC.

ACVR1B/Activin RIB, His, Human

ACVR1B/Activin RIB, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ACVR1B/Activin RIB, His, Human

ACVR1B/Activin RIB, His, Human, His Tag Tag immobilized on CM5 Chip can bind Human TDGF1, His Tag with an affinity constant of 0.16 μM as determined in SPR assay (Biacore T200).

ACVR1B/Activin RIB, His, Human

Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system
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Product Introduction
Species Human
Protein Construction
ACVR1B/Activin RIB (Ser24-Glu126)
Accession # P36896-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 12.51 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 15-25 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • ACVR1B/Activin RIB, His, Human
    • ACVR1B/Activin RIB, His, Human

    The purity of ACVR1B/Activin RIB, His, Human is greater than 95% as determined by SEC-HPLC.

  • ACVR1B/Activin RIB, His, Human
    • ACVR1B/Activin RIB, His, Human

    ACVR1B/Activin RIB, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • ACVR1B/Activin RIB, His, Human
    • ACVR1B/Activin RIB, His, Human

    ACVR1B/Activin RIB, His, Human, His Tag Tag immobilized on CM5 Chip can bind Human TDGF1, His Tag with an affinity constant of 0.16 μM as determined in SPR assay (Biacore T200).


Background
Target Background Activin A receptor type I (ACVR1) encodes for a bone morphogenetic protein type I receptor of the TGFβ receptor superfamily. It is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. Moreover, ACVR1 has been extensively studied for its causal role in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterised by progressive heterotopic ossification. ACVR1 is linked to different pathologies, including cardiac malformations and alterations in the reproductive system
Synonyms ACVR1B; ACTR-IB; ALK 4; ALK-4; SKR2; ACVRLK4; ALK4; Activin R1B

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.