ACVR1/Activin RI hFc Chimera, Human
ACVR1/Activin RI HFc Chimera, Human

The purity of ACVR1/Activin RI hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

ACVR1/Activin RI HFc Chimera, Human

ACVR1/Activin RI hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ACVR1/Activin RI hFc Chimera, Human

Activin A receptor type I (ACVR1), a transmembrane serine/threonine kinase, belongs to the transforming growth factor-β superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors. Genetic variation in ACVR1 has been associated with a rare disease, fibrodysplasia ossificans progressive, and its somatic alteration is reported in rare cancer diffuse intrinsic pontine glioma.
Z04991
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Product Introduction
Species Human
Protein Construction
ACVR1/Activin RI (Met21-Glu123)
Accession # Q04771		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 37.43 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • ACVR1/Activin RI HFc Chimera, Human
    • ACVR1/Activin RI HFc Chimera, Human

    The purity of ACVR1/Activin RI hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • ACVR1/Activin RI HFc Chimera, Human
    • ACVR1/Activin RI HFc Chimera, Human

    ACVR1/Activin RI hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Activin A receptor type I (ACVR1), a transmembrane serine/threonine kinase, belongs to the transforming growth factor-β superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors. Genetic variation in ACVR1 has been associated with a rare disease, fibrodysplasia ossificans progressive, and its somatic alteration is reported in rare cancer diffuse intrinsic pontine glioma.
Synonyms ACTR-I; ALK-2; ACVR1; SKR1; TSR-I; ACVRLK2; Activin RI; Activin R1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.