Activin RIIB/ACVR2B mFc Chimera, Human/Cynomolgus

Activin RIIB/ACVR2B mFc Chimera, Human/Cynomolgus

ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myostatin (MSTN), growth differentiation factor 11 (GDF11), and bone morphogenetic protein 9 (BMP9).
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Product Introduction
Species Human/Cynomolgus
Protein Construction
Activin RIIB/ACVR2B [Ser19-Thr137 (Human) / Ser40-Thr158 (Cynomolgus)]
Accession # Q13705-1 (Human) / XP_045242398.1 (Cynomolgus)		 mFc (IgG1)
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human Activin A, No Tag at 5μg/ml (100 μl/well) on the plate can bind Activin RIIB/ACVR2B mFc Chimera, Human/Cynomolgus. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 39.32 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background ActRIIB (activin receptor type-2B) is an activin receptor subtype constitutively expressed in the whole body, playing a role in cellular proliferation, differentiation, and metabolism. For its various physiological activities, ActRIIB interacts with activin and multiple other ligands including myostatin (MSTN), growth differentiation factor 11 (GDF11), and bone morphogenetic protein 9 (BMP9).
Synonyms Activin receptor type-2B; ACVR2B; Activin RIIB

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.