VSIG4, His, Cynomolgus
VSIG4, His, Cynomolgus

The purity of VSIG4, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

VSIG4, His, Cynomolgus

VSIG4, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

VSIG4, His, Cynomolgus

VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.T cell activation by APCs is positively and negatively regulated by members of the B7 family. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.
Z04941
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Product Introduction
Species Cynomolgus
Protein Construction
VSIG4 (Arg25-Ala288)
Accession # A0A7N9D9P6		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 30.16 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • VSIG4, His, Cynomolgus
    • VSIG4, His, Cynomolgus

    The purity of VSIG4, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • VSIG4, His, Cynomolgus
    • VSIG4, His, Cynomolgus

    VSIG4, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.T cell activation by APCs is positively and negatively regulated by members of the B7 family. Unlike that of B7 family members, surface expression of VSIG4 was restricted to resting tissue macrophages and absent upon activation by LPS or in autoimmune inflammatory foci. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues.
Synonyms CRIg; Z39IG; VSIG4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.