TYRO3, His, Cynomolgus
TYRO3, His, Cynomolgus

The purity of TYRO3, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

TYRO3, His, Cynomolgus

TYRO3, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TYRO3, His, Cynomolgus

The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
Z04939
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Product Introduction
Species Cynomolgus
Protein Construction
TYRO3 (Gly41-Ser427)
Accession # A0A2K5WCY8		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 42.47 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • TYRO3, His, Cynomolgus
    • TYRO3, His, Cynomolgus

    The purity of TYRO3, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • TYRO3, His, Cynomolgus
    • TYRO3, His, Cynomolgus

    TYRO3, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the 'eat-me' signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
Synonyms BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.