TNFR2/CD120b/TNFRSF1B, His, Cynomolgus
TNFR2/CD120b/TNFRSF1B, His, Cynomolgus

Immobilized TNFR2/CD120b/TNFRSF1B, His, Cynomolgus, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-TNFR2 Antibody, hFc Tag with the EC50 of 6.0ng/ml determined by ELISA.

TNFR2/CD120b/TNFRSF1B, His, Cynomolgus

The purity of TNFR2/CD120b/TNFRSF1B, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

TNFR2/CD120b/TNFRSF1B, His, Cynomolgus

TNFR2/CD120b/TNFRSF1B, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TNFR2/CD120b/TNFRSF1B, His, Cynomolgus

Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Z04929
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Product Introduction
Species Cynomolgus
Protein Construction
TNFR2/CD120b/TNFRSF1B (Leu23-Asp257)
Accession # A0A2K5VEV7		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 26.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 49-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • TNFR2/CD120b/TNFRSF1B, His, Cynomolgus
    • TNFR2/CD120b/TNFRSF1B, His, Cynomolgus

    Immobilized TNFR2/CD120b/TNFRSF1B, His, Cynomolgus, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-TNFR2 Antibody, hFc Tag with the EC50 of 6.0ng/ml determined by ELISA.

  • TNFR2/CD120b/TNFRSF1B, His, Cynomolgus
    • TNFR2/CD120b/TNFRSF1B, His, Cynomolgus

    The purity of TNFR2/CD120b/TNFRSF1B, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • TNFR2/CD120b/TNFRSF1B, His, Cynomolgus
    • TNFR2/CD120b/TNFRSF1B, His, Cynomolgus

    TNFR2/CD120b/TNFRSF1B, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Synonyms CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFRSF1B

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.