TIM-3/HAVCR2, His, Cynomolgus
TIM-3/HAVCR2, His, Cynomolgus

Immobilized TIM-3/HAVCR2, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Tim-3 Antibody, hFc Tag with the EC50 of 3.3 ng/ml determined by ELISA.

TIM-3/HAVCR2, His, Cynomolgus

TIM-3/HAVCR2, His, Cynomolguson Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TIM-3/HAVCR2, His, Cynomolgus

Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Z04924
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Product Introduction
Species Cynomolgus
Protein Construction
TIM-3/HAVCR2 (Ser22-Arg201)
Accession # EHH54703.1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized TIM-3/HAVCR2, His, Cynomolgus at 1μg/ml (100μl/well) on the plate can bind Anti­TIM­3 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 20.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • TIM-3/HAVCR2, His, Cynomolgus
    • TIM-3/HAVCR2, His, Cynomolgus

    Immobilized TIM-3/HAVCR2, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Tim-3 Antibody, hFc Tag with the EC50 of 3.3 ng/ml determined by ELISA.

  • TIM-3/HAVCR2, His, Cynomolgus
    • TIM-3/HAVCR2, His, Cynomolgus

    TIM-3/HAVCR2, His, Cynomolguson Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Synonyms CD366; TIM3; TIM-3; TIMD-3; TIM 3; FLJ14428; HAVCR2; KIM3

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.