SPP1/OPN, His, Cynomolgus
SPP1/OPN, His, Cynomolgus

The purity of SPP1/OPN, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

SPP1/OPN, His, Cynomolgus

SPP1/OPN, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SPP1/OPN, His, Cynomolgus

Ovarian cancer is one of the most lethal malignant tumors in women. Secreted phosphoprotein 1 (SPP1) plays an important role in some cancer types. The expression of SPP1 was higher in epithelial ovarian cancer tissues than in normal ovarian tissues. Silencing SPP1 decreased the cell proliferation, migration, and invasion. Ectopic expression of SPP1 increased the cell proliferation, migration, and invasion. Silencing SPP1 prevented ovarian cancer growth in mice. Silencing SPP1 inhibited Integrin β1/FAK/AKT pathway.
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Product Introduction
Species Cynomolgus
Protein Construction
SPP1/OPN (Leu17-Asn300)
Accession # A0A2K5WL90		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 33.16 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • SPP1/OPN, His, Cynomolgus
    • SPP1/OPN, His, Cynomolgus

    The purity of SPP1/OPN, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • SPP1/OPN, His, Cynomolgus
    • SPP1/OPN, His, Cynomolgus

    SPP1/OPN, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Ovarian cancer is one of the most lethal malignant tumors in women. Secreted phosphoprotein 1 (SPP1) plays an important role in some cancer types. The expression of SPP1 was higher in epithelial ovarian cancer tissues than in normal ovarian tissues. Silencing SPP1 decreased the cell proliferation, migration, and invasion. Ectopic expression of SPP1 increased the cell proliferation, migration, and invasion. Silencing SPP1 prevented ovarian cancer growth in mice. Silencing SPP1 inhibited Integrin β1/FAK/AKT pathway.
Synonyms Osteopontin; Bone sialoprotein 1; Nephropontin; SPP-1; BNSP; OPN; SPP1; Uropontin; BSP-1; ETA-1; BSPI

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.