PVRIG, His, Cynomolgus
PVRIG, His, Cynomolgus

Immobilized PVRIG, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 2.0ng/ml determined by ELISA.

PVRIG, His, Cynomolgus

The purity of PVRIG, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

PVRIG, His, Cynomolgus

PVRIG, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PVRIG, His, Cynomolgus

PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Z04904
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Product Introduction
Species Cynomolgus
Protein Construction
PVRIG (Thr41-Asp171)
Accession # A0A2K5WVV8		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 14.78 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • PVRIG, His, Cynomolgus
    • PVRIG, His, Cynomolgus

    Immobilized PVRIG, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-PVRIG Antibody, hFc Tag with the EC50 of 2.0ng/ml determined by ELISA.

  • PVRIG, His, Cynomolgus
    • PVRIG, His, Cynomolgus

    The purity of PVRIG, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • PVRIG, His, Cynomolgus
    • PVRIG, His, Cynomolgus

    PVRIG, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Synonyms C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.