OSMR, His, Cynomolgus
OSMR, His, Cynomolgus

Loaded Anti-OSMR Antibody, hFc Tag on ProA-Biosensor can bind OSMR, His, Cynomolgus, His Tag with an affinity constant of 1.75 nM as determined in BLI assay (Gator® Prime).

OSMR, His, Cynomolgus

Immobilized OSMR, His, Cynomolgus, His Tag at 2 μg /ml (100 μl /well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA.

OSMR, His, Cynomolgus

The purity of OSMR, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

OSMR, His, Cynomolgus

OSMR, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

OSMR, His, Cynomolgus

OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.
Z04889
¥72,752.00

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Product Introduction
Species Cynomolgus
Protein Construction
OSMR (Glu28-Ser737)
Accession # A0A2K5UFW5		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 82.04 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-130 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • OSMR, His, Cynomolgus
    • OSMR, His, Cynomolgus

    Loaded Anti-OSMR Antibody, hFc Tag on ProA-Biosensor can bind OSMR, His, Cynomolgus, His Tag with an affinity constant of 1.75 nM as determined in BLI assay (Gator® Prime).

  • OSMR, His, Cynomolgus
    • OSMR, His, Cynomolgus

    Immobilized OSMR, His, Cynomolgus, His Tag at 2 μg /ml (100 μl /well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA.

  • OSMR, His, Cynomolgus
    • OSMR, His, Cynomolgus

    The purity of OSMR, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • OSMR, His, Cynomolgus
    • OSMR, His, Cynomolgus

    OSMR, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death.
Synonyms IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ;IL-31R subunit β; IL-31R-β; OSMR β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.