Oncostatin M/OSM, His, Cynomolgus
Oncostatin M/OSM, His, Cynomolgus

The purity of Oncostatin M/OSM, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

Oncostatin M/OSM, His, Cynomolgus

Oncostatin M/OSM, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Oncostatin M/OSM, His, Cynomolgus

Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Oncostatin M/OSM, His, Cynomolgus, His Tag with an affinity constant of 1.31 μM as determined in SPR assay (Biacore T200).

Oncostatin M/OSM, His, Cynomolgus

OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Z04888
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Product Introduction
Species Cynomolgus
Protein Construction
Oncostatin M/OSM (Ala27-Arg221)
Accession # XP_045219762.1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Oncostatin M/OSM, His, Cynomolgus in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 23.31 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 27-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Oncostatin M/OSM, His, Cynomolgus
    • Oncostatin M/OSM, His, Cynomolgus

    The purity of Oncostatin M/OSM, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • Oncostatin M/OSM, His, Cynomolgus
    • Oncostatin M/OSM, His, Cynomolgus

    Oncostatin M/OSM, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Oncostatin M/OSM, His, Cynomolgus
    • Oncostatin M/OSM, His, Cynomolgus

    Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Oncostatin M/OSM, His, Cynomolgus, His Tag with an affinity constant of 1.31 μM as determined in SPR assay (Biacore T200).


Background
Target Background OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Synonyms Oncostatin M; OSM

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.