MASP2, His, Cynomolgus
MASP2, His, Cynomolgus

Immobilized MASP2, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-MASP2 Antibody, hFc Tag with the EC50 of 11.9 ng/ml determined by ELISA.

MASP2, His, Cynomolgus

MASP2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MASP2, His, Cynomolgus

The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is observed with the middle east respiratory syndrome (MERS), severe acquired respiratory syndrome (SARS), and SARS-CoV-2. Activation of the lectin pathway via mannose-binding lectin associated serine protease 2 (MASP2) is witnessed under discrete viral infections including COVID-19.
Z04866
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Product Introduction
Species Cynomolgus
Protein Construction
MASP2 (Thr287-Phe686)
Accession # A0A2K5UJY0		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized MASP2, His, Cynomolgus at 1μg/ml (100μl/well) on the plate can bind Anti­MASP2 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 46.8 kDa
Apparent Molecular Weight Due to autocatalytic cleavage, the protein migrates to 21-24 kDa&28-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM Tris, 200mM NaCl (pH 9.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MASP2, His, Cynomolgus
    • MASP2, His, Cynomolgus

    Immobilized MASP2, His, Cynomolgus, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-MASP2 Antibody, hFc Tag with the EC50 of 11.9 ng/ml determined by ELISA.

  • MASP2, His, Cynomolgus
    • MASP2, His, Cynomolgus

    MASP2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is observed with the middle east respiratory syndrome (MERS), severe acquired respiratory syndrome (SARS), and SARS-CoV-2. Activation of the lectin pathway via mannose-binding lectin associated serine protease 2 (MASP2) is witnessed under discrete viral infections including COVID-19.
Synonyms MAP19; MASP-2; MASP1P1; sMap

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.