LY6G6D, His, Cynomolgus
LY6G6D, His, Cynomolgus

Immobilized LY6G6D, His, Cynomolgus, His Tag at 1 μg/ml(100 μl/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 3.3 ng/ml determined by ELISA.

LY6G6D, His, Cynomolgus

LY6G6D, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

LY6G6D, His, Cynomolgus

LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.
Z04864
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Product Introduction
Species Cynomolgus
Protein Construction
His LY6G6D (Asn20-Ser104)
Accession # XP_014991478.1
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. ImmobilizedL Y6G6D, His, Cynomolgus at 1μg/ml (100μl/well) on the plate can bind Anti­LY6G6D Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 10.22 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 14-24 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • LY6G6D, His, Cynomolgus
    • LY6G6D, His, Cynomolgus

    Immobilized LY6G6D, His, Cynomolgus, His Tag at 1 μg/ml(100 μl/well) on the plate. Dose response curve for Anti-LY6G6D Antibody, hFc Tag with the EC50 of 3.3 ng/ml determined by ELISA.

  • LY6G6D, His, Cynomolgus
    • LY6G6D, His, Cynomolgus

    LY6G6D, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy.
Synonyms Protein Ly6-D; C6orf23; G6D; MEGT1; NG25

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.