KLKB1, His, Cynomolgus

KLKB1, His, Cynomolgus

Plasma kallikrein, also known as Fletcher factor or kallikrein B1 (KLKB1), is a serine endopeptidase, like its homologs tissue kallikrein and kallikrein-related peptidases (KLKs). Its physiological role is to catalyze the release of kinins and other vasoactive peptides.
Z04851
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Product Introduction
Species Cynomolgus
Protein Construction
KLKB1 (Gly20-Ala638)
Accession # A0A2K5VTJ9		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its ability to cleave a flourogenic peptide substrate Pro­Phe­Arg­7­amido­4­methylcoumarin (PFRAMC). The specific activity is > 800 pmol/min/μg. Test result meets the standard.
Expression System HEK293
Theoretical Molecular Weight 70.19 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM NaAc, 150mM NaCl (pH 5.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 20mM NaAc, 150mM NaCl (pH 5.0).
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Plasma kallikrein, also known as Fletcher factor or kallikrein B1 (KLKB1), is a serine endopeptidase, like its homologs tissue kallikrein and kallikrein-related peptidases (KLKs). Its physiological role is to catalyze the release of kinins and other vasoactive peptides.
Synonyms Plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.