Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Cynomolgus

Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Cynomolgus

The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules. It plays a critical role in platelet function and homeostasis.
Z04849
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Product Introduction
Species Cynomolgus
Protein Construction
Integrin alpha 2 beta 1 (ITGA2 & ITGB1) Heterodimer [Tyr30-Pro1130 (ITGA2) acidic tail and Gln161-Asp868 (ITGB1) basic tail]
Accession # G8F2Z5 (ITGA2) & A0A7N9D0D7 (ITGB1)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 126.69 kDa (ITGA2) and 83.16 kDa (ITGB1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 130-170 kDa (ITGA2) and 100-130 kDa (ITGB1) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules. It plays a critical role in platelet function and homeostasis.
Synonyms α2β1; Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; VLA-2, GPIa-IIa, CD49b;Integrin alpha A1 β 1; alpha A1 β 1; β 1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.