IL-23R, His, Cynomolgus
IL-23R, His, Cynomolgus

Immobilized IL-23R, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.39 μg/ml determined by ELISA.

IL-23R, His, Cynomolgus

IL-23R, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-23R, His, Cynomolgus

The purity of IL-23R, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

IL-23R, His, Cynomolgus

IL-23R, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-23 alpha&Mouse IL-12 beta, His Tag with an affinity constant of 3.90 nM as determined in SPR assay (Biacore T200).

IL-23R, His, Cynomolgus

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
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Product Introduction
Species Cynomolgus
Protein Construction
IL-23R (Gly24-Asp353)
Accession # G7NWY5		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized IL-23R, His, Cynomolgus at 5μg/ml (100μl/well) on the plate can bind Biotinylated Human IL­23 alpha&IL­12 beta, His Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 39.03 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-23R, His, Cynomolgus
    • IL-23R, His, Cynomolgus

    Immobilized IL-23R, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 0.39 μg/ml determined by ELISA.

  • IL-23R, His, Cynomolgus
    • IL-23R, His, Cynomolgus

    IL-23R, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-23R, His, Cynomolgus
    • IL-23R, His, Cynomolgus

    The purity of IL-23R, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • IL-23R, His, Cynomolgus
    • IL-23R, His, Cynomolgus

    IL-23R, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-23 alpha&Mouse IL-12 beta, His Tag with an affinity constant of 3.90 nM as determined in SPR assay (Biacore T200).


Background
Target Background Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
Synonyms IBD17; IL-23 R; IL-23 receptor

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.