IL-22R alpha 1, His, Cynomolgus
IL-22R Alpha 1, His, Cynomolgus

The purity of IL-22R alpha 1, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

IL-22R Alpha 1, His, Cynomolgus

IL-22R alpha 1, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-22R Alpha 1, His, Cynomolgus

IL-22R alpha 1, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-22, His Tag with an affinity constant of 60.21 nM as determined in SPR assay (Biacore T200).

IL-22R alpha 1, His, Cynomolgus

IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Z04836
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Product Introduction
Species Cynomolgus
Protein Construction
IL-22R alpha 1 (Pro18-Thr225)
Accession # A0A2K5TKX9		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 24.84 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 38-45 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-22R Alpha 1, His, Cynomolgus
    • IL-22R Alpha 1, His, Cynomolgus

    The purity of IL-22R alpha 1, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • IL-22R Alpha 1, His, Cynomolgus
    • IL-22R Alpha 1, His, Cynomolgus

    IL-22R alpha 1, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-22R Alpha 1, His, Cynomolgus
    • IL-22R Alpha 1, His, Cynomolgus

    IL-22R alpha 1, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-22, His Tag with an affinity constant of 60.21 nM as determined in SPR assay (Biacore T200).


Background
Target Background IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Synonyms IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.