IL-1 Beta/IL-1F2, His, Cynomolgus
IL-1 Beta/IL-1F2, His, Cynomolgus

The purity of IL-1 Beta/IL-1F2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

IL-1 Beta/IL-1F2, His, Cynomolgus

IL-1 Beta/IL-1F2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-1 Beta/IL-1F2, His, Cynomolgus

Human IL-1 RII, hFc Tag captured on CM5 Chip via Protein A can bind IL-1 Beta/IL-1F2, His, Cynomolgus, His Tag with an affinity constant of 1.40 nM as determined in SPR assay (Biacore T200).

IL-1 Beta/IL-1F2, His, Cynomolgus

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells.
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Product Introduction
Species Cynomolgus
Protein Construction
IL-1 Beta/IL-1F2 (Ala117-Ser268)
Accession # A0A2K5VDC7		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IL­1 RII, hFc Tag captured on CM5 Chip via Protein A can bind IL-1 Beta/IL-1F2, His, Cynomolgus in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 18.33 kDa
Apparent Molecular Weight The protein has a predicted MW of 18.33 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS,100mM L-arginine (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-1 Beta/IL-1F2, His, Cynomolgus
    • IL-1 Beta/IL-1F2, His, Cynomolgus

    The purity of IL-1 Beta/IL-1F2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • IL-1 Beta/IL-1F2, His, Cynomolgus
    • IL-1 Beta/IL-1F2, His, Cynomolgus

    IL-1 Beta/IL-1F2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-1 Beta/IL-1F2, His, Cynomolgus
    • IL-1 Beta/IL-1F2, His, Cynomolgus

    Human IL-1 RII, hFc Tag captured on CM5 Chip via Protein A can bind IL-1 Beta/IL-1F2, His, Cynomolgus, His Tag with an affinity constant of 1.40 nM as determined in SPR assay (Biacore T200).


Background
Target Background Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells.
Synonyms Interleukin-1 beta; IL-1 beta; IL1F2; IL1B; IL-1BETA; IL1F2; IL-1β; IL-1 beta; IL-1B ;Interleukin-1 β; IL-1 β; IL-1β; IL-1 β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.