IL-1 alpha/IL-1A, Cynomolgus
IL-1 Alpha/IL-1A, Cynomolgus

The purity of IL-1 alpha/IL-1A, Cynomolgus is greater than 95% as determined by SEC-HPLC.

IL-1 Alpha/IL-1A, Cynomolgus

IL-1 alpha/IL-1A, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-1 Alpha/IL-1A, Cynomolgus

Human IL-1R1, His Tag immobilized on CM5 Chip can bind IL-1 alpha/IL-1A, Cynomolgus, No Tag with an affinity constant of 10.68 μM as determined in SPR assay (Biacore T200).

IL-1 alpha/IL-1A, Cynomolgus

The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
Z04817
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Product Introduction
Species Cynomolgus
Protein Construction
IL-1 alpha/IL-1A (Ser113-Ala271)
Accession # P79340
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 18.13 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 26-33 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-1 Alpha/IL-1A, Cynomolgus
    • IL-1 Alpha/IL-1A, Cynomolgus

    The purity of IL-1 alpha/IL-1A, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • IL-1 Alpha/IL-1A, Cynomolgus
    • IL-1 Alpha/IL-1A, Cynomolgus

    IL-1 alpha/IL-1A, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-1 Alpha/IL-1A, Cynomolgus
    • IL-1 Alpha/IL-1A, Cynomolgus

    Human IL-1R1, His Tag immobilized on CM5 Chip can bind IL-1 alpha/IL-1A, Cynomolgus, No Tag with an affinity constant of 10.68 μM as determined in SPR assay (Biacore T200).


Background
Target Background The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
Synonyms Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1; IL-1 ALPHA; IL1α; IL-1A; IL1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.