GITR/TNFRSF18, His, Cynomolgus
GITR/TNFRSF18, His, Cynomolgus

Immobilized GITR/TNFRSF18, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 2.4 ng/ml determined by ELISA.

GITR/TNFRSF18, His, Cynomolgus

GITR/TNFRSF18, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GITR/TNFRSF18, His, Cynomolgus

GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Z04803
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Product Introduction
Species Cynomolgus
Protein Construction
GITR/TNFRSF18 (Gln20-Pro156)
Accession # XP_005545180.2		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized GITR/TNFRSF18, His, Cynomolgus at 0.5μg/ml (100μl/well) on the plate can bind Anti­GITR Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 15.87 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • GITR/TNFRSF18, His, Cynomolgus
    • GITR/TNFRSF18, His, Cynomolgus

    Immobilized GITR/TNFRSF18, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GITR Antibody, hFc Tag with the EC50 of 2.4 ng/ml determined by ELISA.

  • GITR/TNFRSF18, His, Cynomolgus
    • GITR/TNFRSF18, His, Cynomolgus

    GITR/TNFRSF18, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Synonyms CD357; GITR; GITR-D; TNFRSF18; AITR

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.