GDF15, His, Cynomolgus
GDF15, His, Cynomolgus

Immobilized GDF15, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA.

GDF15, His, Cynomolgus

Immobilized GDF15, His, Cynomolgus , His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA.

GDF15, His, Cynomolgus

GDF15, His, Cynomolgus on Bis-Tris PAGE under reduced (R) condition and Non reduced (N) condition. The purity is greater than 95%.

GDF15, His, Cynomolgus

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
Z04799
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Product Introduction
Species Cynomolgus
Protein Construction
His GDF15 (Arg193-Val308)
Accession # G7PWZ3
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 14.15 kDa
Apparent Molecular Weight The protein migrates to 15-18 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in 50mM HAc (pH 2.9).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM HAc (pH 2.9).
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • GDF15, His, Cynomolgus
    • GDF15, His, Cynomolgus

    Immobilized GDF15, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Cynomolgus GFRAL, His Tag with the EC50 of 39.9 ng/ml determined by ELISA.

  • GDF15, His, Cynomolgus
    • GDF15, His, Cynomolgus

    Immobilized GDF15, His, Cynomolgus , His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GDF15 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA.

  • GDF15, His, Cynomolgus
    • GDF15, His, Cynomolgus

    GDF15, His, Cynomolgus on Bis-Tris PAGE under reduced (R) condition and Non reduced (N) condition. The purity is greater than 95%.


Background
Target Background Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
Synonyms GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.