Fc gamma RIII/CD16, His, Cynomolgus
Fc Gamma RIII/CD16, His, Cynomolgus

The purity of Fc gamma RIII/CD16, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

Fc Gamma RIII/CD16, His, Cynomolgus

Fc gamma RIII/CD16, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Fc Gamma RIII/CD16, His, Cynomolgus

Rituximab captured on CM5 Chip via Protein A can bind Fc gamma RIII/CD16, His, Cynomolgus, His Tag with an affinity constant of 0.251 μM as determined in SPR assay (Biacore T200).

Fc gamma RIII/CD16, His, Cynomolgus

Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.
Z04788
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Product Introduction
Species Cynomolgus
Protein Construction
Fc gamma RIII/CD16 (Gly17-Gln208)
Accession # Q8SPW2-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded Fc gamma RIII/CD16, His, Cynomolgus on Anti­His­Biosensor, can bind Rituximab in BLI assay (Gator). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 23.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Fc Gamma RIII/CD16, His, Cynomolgus
    • Fc Gamma RIII/CD16, His, Cynomolgus

    The purity of Fc gamma RIII/CD16, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • Fc Gamma RIII/CD16, His, Cynomolgus
    • Fc Gamma RIII/CD16, His, Cynomolgus

    Fc gamma RIII/CD16, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • Fc Gamma RIII/CD16, His, Cynomolgus
    • Fc Gamma RIII/CD16, His, Cynomolgus

    Rituximab captured on CM5 Chip via Protein A can bind Fc gamma RIII/CD16, His, Cynomolgus, His Tag with an affinity constant of 0.251 μM as determined in SPR assay (Biacore T200).


Background
Target Background Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated immune responses with cellular effector functions. A high resolution map of the binding site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn receptors has been determined.A common set of IgG1 residues is involved in binding to all Fc gamma R; Fc gamma RII and Fc gamma RIII also utilize residues outside this common set.
Synonyms IgG Fc receptor III; Fc-gamma RIII; FcRIII; FCGR3; CD16; CD16A; FCG3; FcgRIII; FCR-10; FCRIIIA; IGFR3; IMD20

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.