B7-H7/HHLA2, His, Cynomolgus
B7-H7/HHLA2, His, Cynomolgus

The purity of B7-H7/HHLA2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

B7-H7/HHLA2, His, Cynomolgus

B7-H7/HHLA2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

B7-H7/HHLA2, His, Cynomolgus

B7-H7/HHLA2, His, Cynomolgus, His Tag captured on CM5 Chip via anti-his antibody can bind Human CD28H, hFc Tag with an affinity constant of 7.86 nM as determined in SPR assay (Biacore T200).

B7-H7/HHLA2, His, Cynomolgus

B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Z04743
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Product Introduction
Species Cynomolgus
Protein Construction
B7-H7/HHLA2 (Ile21-Asn345)
Accession # XP_005548285.2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity B7-H7/HHLA2, His, Cynomolgus captured on CM5 Chip via anti­his antibody can bind Human CD28H, hFc Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 38.31 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • B7-H7/HHLA2, His, Cynomolgus
    • B7-H7/HHLA2, His, Cynomolgus

    The purity of B7-H7/HHLA2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • B7-H7/HHLA2, His, Cynomolgus
    • B7-H7/HHLA2, His, Cynomolgus

    B7-H7/HHLA2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • B7-H7/HHLA2, His, Cynomolgus
    • B7-H7/HHLA2, His, Cynomolgus

    B7-H7/HHLA2, His, Cynomolgus, His Tag captured on CM5 Chip via anti-his antibody can bind Human CD28H, hFc Tag with an affinity constant of 7.86 nM as determined in SPR assay (Biacore T200).


Background
Target Background B7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins.Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Synonyms B7H7; B7-H7; HHLA2; B7 Homolog 7

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.