B7-H6/NCR3LG1, His, Cynomolgus
B7-H6/NCR3LG1, His, Cynomolgus

The purity of B7-H6/NCR3LG1, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

B7-H6/NCR3LG1, His, Cynomolgus

B7-H6/NCR3LG1, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

B7-H6/NCR3LG1, His, Cynomolgus

Human NKp30, hFc Tag captured on CM5 Chip via Protein A can bind B7-H6/NCR3LG1, His, Cynomolgus, His Tag with an affinity constant of 0.662 μM as determined in SPR assay (Biacore T200).

B7-H6/NCR3LG1, His, Cynomolgus

B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins, which is a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7-H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Z04742
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Product Introduction
Species Cynomolgus
Protein Construction
B7-H6/NCR3LG1 (Asp25-Asp259)
Accession # XP_005578557.1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Human NKp30, hFc Tag captured on CM5 Chip via Protein A can bind B7-H6/NCR3LG1, His, Cynomolgus in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 27.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-52 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • B7-H6/NCR3LG1, His, Cynomolgus
    • B7-H6/NCR3LG1, His, Cynomolgus

    The purity of B7-H6/NCR3LG1, His, Cynomolgus is greater than 95% as determined by SEC-HPLC.

  • B7-H6/NCR3LG1, His, Cynomolgus
    • B7-H6/NCR3LG1, His, Cynomolgus

    B7-H6/NCR3LG1, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • B7-H6/NCR3LG1, His, Cynomolgus
    • B7-H6/NCR3LG1, His, Cynomolgus

    Human NKp30, hFc Tag captured on CM5 Chip via Protein A can bind B7-H6/NCR3LG1, His, Cynomolgus, His Tag with an affinity constant of 0.662 μM as determined in SPR assay (Biacore T200).


Background
Target Background B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins, which is a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7-H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Synonyms B7H6; B7-H6; DKFZp686I21167; DKFZp686O24166; NCR3LG1; B7 Homolog 6

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.