IL-31, His, Canine
IL-31, His, Canine

The purity of IL-31, His, Canine is greater than 95% as determined by SEC-HPLC.

IL-31, His, Canine

IL-31, His, Canine on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-31, His, Canine

Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells.
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Product Introduction
Species Canine
Protein Construction
His IL-31 (Ala27-Gln159)
Accession # BAH97742.1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 16.63 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 26-36 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-31, His, Canine
  • IL-31, His, Canine

    The purity of IL-31, His, Canine is greater than 95% as determined by SEC-HPLC.

  • IL-31, His, Canine
  • IL-31, His, Canine

    IL-31, His, Canine on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells.
Synonyms Interleukin-31; IL-31;IL31

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.