Oncostatin M/OSM[Biotin], His & Avi, Human
Oncostatin M/OSM[Biotin], His & Avi, Human

The purity of Oncostatin M/OSM[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

Oncostatin M/OSM[Biotin], His & Avi, Human

Oncostatin M/OSM[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

Oncostatin M/OSM[Biotin], His & Avi, Human

Human LIF R, His Tag immobilized on CM5 Chip can bind Oncostatin M/OSM[Biotin], His & Avi, Human, His Tag with an affinity constant of 0.94 μM as determined in SPR assay (Biacore T200).

Oncostatin M/OSM[Biotin], His & Avi, Human

OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Z04576
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Product Introduction
Species Human
Protein Construction
Oncostatin M/OSM (Ala26-Arg221)
Accession # P13725		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 25.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Oncostatin M/OSM[Biotin], His & Avi, Human
    • Oncostatin M/OSM[Biotin], His & Avi, Human

    The purity of Oncostatin M/OSM[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • Oncostatin M/OSM[Biotin], His & Avi, Human
    • Oncostatin M/OSM[Biotin], His & Avi, Human

    Oncostatin M/OSM[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

  • Oncostatin M/OSM[Biotin], His & Avi, Human
    • Oncostatin M/OSM[Biotin], His & Avi, Human

    Human LIF R, His Tag immobilized on CM5 Chip can bind Oncostatin M/OSM[Biotin], His & Avi, Human, His Tag with an affinity constant of 0.94 μM as determined in SPR assay (Biacore T200).


Background
Target Background OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Synonyms Oncostatin M; OSM; MGC20461

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.