NRG1 Beta 1 hFc Chimera[Biotin], Human

NRG1 Beta 1 hFc Chimera[Biotin], Human

euregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.
Z04575
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Product Introduction
Species Human
Protein Construction
hFc NRG1 Beta 1 (Ser2-Lys246)
Accession # Q02297-6
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human Her4, His Tag at 5μg/ml (100μl/well) on the plate can bind NRG1 Beta 1 hFc Chimera[Biotin], Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 54.00 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-90 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background euregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor.
Synonyms Pro-NRG1; NRG1; GGF; HGL; HRGA; NDF; SMDF; Beta1; Beta1A

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.