Immobilized Notch 1[Biotin], His & Avi, Human, His Avi Tag at 2 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human DLL4, hFc Tag with the EC50 of 8.1ng/ml determined by ELISA.
The purity of Notch 1[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC.
Notch 1[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
Human DLL4, hFc Tag captured on CM5 Chip via Protein A can bind Notch 1[Biotin], His & Avi, Human, His Tag with an affinity constant of 0.31 μM as determined in SPR assay (Biacore T200).
Notch 1[Biotin], His & Avi, Human
Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
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